Compare Online Weight Loss Treatments
See how online weight loss programs differ in medication options, clinician support and cost, then start with the one that fits you.
Updated November 2026
- 1Best overall
TrimRx
- Injectable and oral GLP-1 options
- Online visit with a licensed clinician
- Medication shipped to your home
- 2Wide range of plans
Direct Meds
- Semaglutide and tirzepatide plans
- Injections or oral options
- Prescribed after an online assessment
- 3Best for habit support
Noom
- Medication paired with a behavior-change app
- Access to licensed clinicians online
- Often FSA/HSA eligible
- 4
Sunlight
- Personalized treatment plan
- No insurance required
- Ongoing clinical guidance
- 5
Lemonaid Health
- GLP-1 programs with monthly billing
- Care from licensed medical providers
- Fully online
- 6Best for insurance checks
Ro
- Checks insurance coverage for brand-name options
- Brand-name GLP-1 medications available
- Online visit, home delivery
Before you start
GLP-1 medications such as semaglutide and tirzepatide need a prescription. A clinician will review your health history to decide if they suit you. Brand-name versions (like Wegovy® and Zepbound®) are FDA-approved; compounded versions are not FDA-approved.
Common side effects include nausea and stomach upset. These medications are not for people with a personal or family history of medullary thyroid cancer or MEN 2.